Morioka S*, Kajioka D, Yamaoka Y, Ellison R.M, Tufan T, Werkman I. L, Tanaka S, Barron B, Ito T.S,  Kucenas S, Okusa M.D and Ravichandran K. S*

Chimeric efferocytic receptors improve apoptotic cell clearance and alleviate inflammation.

 *Corresponding authors

Cell (2022) 185(26):4887-4903.e17.

 

Raymond MH, Davidson AJ, Shen Y, Tudor DR, Morioka S, Perry J.S.A Krapivkina J,Perrasis D., Schumancher L, Campbell RE, Wood W, and Ravichandran K.S.

Live cell tracking of macrophage efferocytosis during Drosophila embryo in vivo.

Science (2022) 375, 1182–1187

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Medina C.B, Mehrotra P, Arandjelovic S, Perry J. S. A, Guo Y, Morioka S, Barron B, Walk S.F., Ghesquière B, Krupnick A.S, Lorenz U and Ravichandran K. S.

Metabolites released from apoptotic cells act as tissue messengers.

Nature (2020) 580,130–135

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Perry J. S. A†, Morioka S†, Raymond M.H, Medina C.B, Shankman, Onengut-Gumuscu S and Ravichandran K. S.  †Equal contribution

Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway.

Nature Cell Biology (2019) 21, pages1532–1543 

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Rival C.M, Xu C, Shankman L. S, Morioka S, Arandjelovic S, Lee C.S, Wheeler K. M, Smith R.P, Haney L.B, Isakson B.E, Purcell S, Lysiak J.J and Ravichandran K. S. 

PtdSer on viable sperm and phagocytic machinery components in oocytes as new players in sperm:egg fusion.

Nature Communications (2019) 10, 4456 

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Morioka S, Perry J. S. A, Raymond M. H, Medina C.B, Zhu Y, Zhao L, Serbulea V, Onengut-Gumuscu S, Letinger N, Kucenas S, Rathmell J.C, Makowski L and Ravichandran K. S.

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release. 

Nature (2018) 563, 714–718

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Mihaly SR†, Sakamachi Y, Ninomiya-Tsuji J and Morioka S†*.

Noncanonical cell death program independent of caspase activation cascade and necroptotic modules is elicited by loss of TGFβ-activated kinase 1. †Equal contribution *Corresponding author

Scientific Reports (2017) 7: 2918

　

Michaels AD, Newhook TE, Adair SJ, Morioka S, Goudreau BJ, Nagdas S, Mullen MG, Persily JB, Bullock T, Slingluff CL, Ravichandran KS, Parsons JT, Bauer TW.

CD47 Blockade as an Adjuvant Immunotherapy for Resectable Pancreatic Cancer.

Clinical Cancer Research (2017)

 

Sakamachi Y, Morioka S, Sai K, Takaesu G, Foley JF, Fessler MB, Ninomiya-Tsuji J.

TAK1 regulates thymic and lung morphogenesis through protecting lysosome integrity in macrophages.

Cell Death and Disease (2017) 8, e2598.

 

Morioka S*, Sai K, Omori E, Ikeda Y, Matsumoto K and Ninomiya-Tsuji J *.

TAK1 regulates hepatic lipid homeostasis through SREBP. *Corresponding authors

Oncogene (2016) 35, 3829–3838.

 

Sai K, Morioka S, Takaesu G, Muthusamy N, Ghashghaei HT, Hanafusa H, Matsumoto K, and Ninomiya-Tsuji J.

TAK1 determines susceptibility to endoplasmic reticulum stress and hypothalamic leptin resistance.

Journal of Cell Science (2016) 129(9):1855-65.

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Mihaly SR, Morioka S, Ninomiya-Tsuji J and Takaesu G.

Activated macrophage survival is coordinated by TAK1 binding proteins.

PLOS ONE (2014) 9(4):e94982

 

Morioka S, Broglie P, Omori E, Ikeda Y, Takaesu G, Matsumoto K and Ninomiya-Tsuji J.

TAK1 kinase switches cell fate from apoptosis to necrosis following TNFα stimulation.

The Journal of Cell Biology (2014) 204 (4), 607-623

 

Ikeda Y, Morioka S, Matsumoto K and Ninomiya-Tsuji J.

TAK1 binding protein 2 is essential for liver protection from stressors.

PLOS ONE (2014) 9 (2): e88037

 

Morioka S, Inagaki M, Komatsu Y, Mishina Y, Matsumoto K and Ninomiya-Tsuji J.

TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration.

Blood (2012) 120, 3846-3857

 

Morioka S, Omori E, Kajino T, Kajino-Sakamoto R, Matsumoto K and Ninomiya-Tsuji J.

TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP.

Oncogene (2009) (Featured article) 28, 2257-2265

 

Omori E, Morioka S, Matsumoto K, and Ninomiya-Tsuji J.

TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity. 

Journal of Biological Chemistry (2008) 283, 26161-26168